Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon

被引：68

作者：

Varea, E. ^{[1
]}

Castillo-Gomez, E. ^{[1
]}

Gomez-Climent, M. A. ^{[1
]}

Blasco-Ibanez, J. M. ^{[1
]}

Crespo, C. ^{[1
]}

Martinez-Guijaro, F. J. ^{[1
]}

Nacher, J. ^{[1
]}

机构：

[1] Univ Valencia, Dept Cell Biol, Neurobiol Unit, Program Basic & Appl Neurosci, Valencia, Spain

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2007年 / 17卷 / 08期

关键词：

amygdata; hippocampus; medial prefrontal cortex; interneuron; structural plasticity;

D O I：

10.1016/j.euroneuro.2007.01.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Structural modifications occur in the brain of severely depressed patients and they can be reversed by antidepressant treatment. Some of these changes do not occur in the same direction in different regions, such as the medial. prefrontal cortex, the hippocampus or the amygdala. Differential structural plasticity also occurs in animal models of depression and it is also prevented by antidepressants. In order to know whether chronic ftuoxetine treatment induces differential neuronal structural plasticity in rats, we have analyzed the expression of synaptophysin, a protein considered a marker of synaptic density, and the expression of the polysiatytated form of the neural cell adhesion molecule (PSA-NCAM), a molecule involved in neurite and synaptic remodeling. Chronic ftuoxetine treatment increases synaptophysin and PSANCAM expression in the medial prefrontal cortex and decreases them in the amygdala. The expression of these molecules is also affected in the entorhinat, the visual and the somatosensory cortices. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：546 / 557

页数：12

共 58 条

[1]

Morphometric studies of the entorhinal cortex in neuropsychiatric patients and controls: clusters of heterotopically displaced lamina II neurons are not indicative of schizophrenia [J].