Combined effects of gender, skin type and polymorphic genes on clinical phenotype: use of rate of increase in numbers of basal cell carcinomas as a model system

被引：37

作者：

Ramachandran, S

Fryer, AA

Lovatt, TJ

Smith, AG

Lear, JT

Jones, PW

Strange, RC ^{[1
]}

机构：

[1] Keele Univ, N Staffordshire Hosp, Sch Med, Ctr Cell & Mol Med, Stoke On Trent ST4 7QB, Staffs, England

[2] Good Hope Hosp, Dept Biochem, Sutton Coldfield B75 7RR, W Midlands, England

[3] N Staffordshire Univ, Dept Dermatol, Stoke On Trent ST4 7QB, Staffs, England

[4] Dept Math, Stoke On Trent ST5 5HG, Staffs, England

来源：

CANCER LETTERS | 2003年 / 189卷 / 02期

关键词：

basal cell carcinoma; cytochrome p450; tumor necrosis factor-alpha; vitamin D receptor; polymorphism;

D O I：

10.1016/S0304-3835(02)00516-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with a basal cell carcinomas (BCC) have an increased risk of further tumors. We studied the individual and combined impact of gender, skin type and allelic genes cytochrome P450 (CYP2D6), vitamin D receptor (VDR), tumor necrosis factor-alpha, TNF-alpha) on the rate of increase in BCC numbers after first presentation. Individually, male gender, skin type 1, CYP2D6 EM, VDR TT and TNF-alpha GG were associated with more BCC/year (rate ratio (RR) 1.20-1.36) while RR for associations of combinations of two, three and four variables were greater than in their reference categories (RR 1.32-1.90, 2.20-2.84, 3.065.49, respectively). The data show that different factors mediate the numbers of BCC/year in males and females and, the individual contributions of variables to risk is modest. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：175 / 181

页数：7

共 19 条

[1] THE VALIDITY AND PRACTICALITY OF SUN-REACTIVE SKIN TYPE-I THROUGH TYPE-VI [J].