Emergence and evolution of functional heavy-chain antibodies in Camelidae

被引：123

作者：

Conrath, KE

Wernery, U

Muyldermans, S

Nguyen, VK

机构：

[1] Free Univ Brussels VIB, Dept Immunol Parasitol & Ultrastruct, B-1640 Rhode St Genese, Belgium

[2] Cent Vet Res Lab, Dubai, U Arab Emirates

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2003年 / 27卷 / 02期

关键词：

combinatorial diversity; immunoglobulins; Camelidae; heavy-chain antibody; SINGLE-DOMAIN ANTIBODY; VACCINATED MELANOMA PATIENT; ENTIRE C(H)1 DOMAIN; B-CELL REPERTOIRE; H GENE FAMILY; V-H; ANTIGEN-BINDING; SOMATIC GENERATION; EFFECTOR FUNCTIONS; LOOP STRUCTURES;

D O I：

10.1016/S0145-305X(02)00071-X

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Antibodies of jawed-vertebrates are composed of paired heavy (H) and light (L) polypeptide chains. Surprisingly, the sera of camelids, nurse shark and wobbegong shark, and possibly ratfish contain antibodies that lack L-chains. In camelids, these Heavy-chain antibodies (HCAbs) are gamma-isotypes, and are functional in antigen binding. In this review we focus on the dedicated immunoglobulin (Ig) genes that encode the HCAb in Camelidae (camels, dromedaries and llamas), about their origin, and how these camel immumoglobulins evolved and acquire a large and diverse repertoire of antigen binding sites in absence of the H-L combinatorial diversity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：87 / 103

页数：17

共 93 条

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