Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters

被引:54
作者
Xu, RP
Yokoyama, WH
Irving, D
Rein, D
Walzem, RL
German, JB [1 ]
机构
[1] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA
[2] Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA
[3] USDA ARS, Western Reg Res Ctr, Albany, CA 94710 USA
关键词
antioxidants; atherosclerosis; catechin; fatty streak accumulation; flavonoids; hamsters; lipoprotein cholesterol; low density lipoproteins; vitamin E;
D O I
10.1016/S0021-9150(97)00248-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Male golden Syrian hamsters were fed for 16 weeks on a hypercholesterolemic diet containing, per kg, 150 g of lipids (90 g butterfat, 35 g vitamin E-stripped corn oil and 25 g fish oil), 2 g cholesterol and either 3 IU vitamin E (3 IU E), 3 IU vitamin E and 200 mg catechin hydrate (3 IU E-200 Cat) or 30 IU vitamin E (30 IU E). More fatty streaks, measured by Oil Red O staining, were deposited in aortas of hamsters fed 3 IU E than in those fed either 3 IU E-200 Cat or 30 IU E. Lipid staining increased with plasma low-density lipoprotein cholesterol (LDL-C) in all animals. At the same concentration of LDL-C, animals fed either 3 IU E-200 Cat or 30 IU E developed less fatty streaks than those fed 3 IU E. Plasma LDL-C and total cholesterol were highest in hamsters fed 3 IU E and LDL-C and total cholesterol in animals fed 3 IU-200 Cat were not different from those fed either 3 IU E or 30 IU E. This study showed the importance of circulating plasma LDL-C on atherogenesis and the inhibitory effect on this process of both dietary vitamin E and catechin. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:29 / 36
页数:8
相关论文
共 44 条