The Distribution and Function of Phosphatidylserine in Cellular Membranes

被引：736

作者：

Leventis, Peter A. ^{[1
]}

Grinstein, Sergio ^{[1
]}

机构：

[1] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 1X8, Canada

来源：

ANNUAL REVIEW OF BIOPHYSICS, VOL 39 | 2010年 / 39卷

基金：

加拿大健康研究院;

关键词：

lipid asymmetry; flippase; scramblase; surface charge; C2; domain; apoptosis; SPIN-LABELED PHOSPHOLIPIDS; YEAST PLASMA-MEMBRANE; LACTADHERIN C2 DOMAIN; P-TYPE ATPASES; SACCHAROMYCES-CEREVISIAE; BLOOD-COAGULATION; ANNEXIN-V; RAT-LIVER; AMINOPHOSPHOLIPID TRANSLOCASE; PROTHROMBINASE COMPLEX;

D O I：

10.1146/annurev.biophys.093008.131234

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly distributed, PS is found preferentially in the inner leaflet of the plasma membrane and in endocytic membranes. The loss of PS asymmetry is an early indicator of apoptosis and serves as a signal to initiate blood clotting. This review discusses the determinants and functional implications of the subcellular distribution and membrane topology of PS.

引用

页码：407 / 427

页数：21

共 109 条

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