Potent Nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

被引：35

作者：

Goetz, MA

Hensens, OD

Zink, DL

Borris, RP

Morales, F

Tamayo-Castillo, G

Slaughter, RS

Felix, J

Ball, RG

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Rahway, NJ 07065 USA

[2] Inst Nacl Biodiversidad, Heredia, Costa Rica

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 19期

关键词：

K-v1.3 channel blockers correolide and dehydrocorreolide; isolation and structure; 2D NMR; HMBC; EI-MS; X-ray;

D O I：

10.1016/S0040-4039(98)00427-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The isolation and structure elucidation of two novel nor-triterpenoid K(V)1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2895 / 2898

页数：4

共 4 条

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