Potent Nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

被引:35
作者
Goetz, MA
Hensens, OD
Zink, DL
Borris, RP
Morales, F
Tamayo-Castillo, G
Slaughter, RS
Felix, J
Ball, RG
机构
[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Rahway, NJ 07065 USA
[2] Inst Nacl Biodiversidad, Heredia, Costa Rica
关键词
K-v1.3 channel blockers correolide and dehydrocorreolide; isolation and structure; 2D NMR; HMBC; EI-MS; X-ray;
D O I
10.1016/S0040-4039(98)00427-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The isolation and structure elucidation of two novel nor-triterpenoid K(V)1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2895 / 2898
页数:4
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