Quantification of 1,3-β-D-glucan levels in children:: Preliminary data for diagnostic use of the β-glucan assay in a pediatric setting

被引：76

作者：

Smith, P. Brian

Benjamin, Daniel K., Jr.

Alexander, Barbara D.

Johnson, Melissa D.

Finkelman, Malcolm A.

Steinbach, William J.

机构：

[1] Duke Univ, Med Ctr, Dept Pediat, Durham, NC USA

[2] Duke Univ, Clin Res Inst, Durham, NC USA

[3] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[4] Associates Cape Cod Inc, Falmouth, MA USA

[5] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27706 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2007年 / 14卷 / 07期

关键词：

D O I：

10.1128/CVI.00025-07

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

1,3-beta-D-Glucan serum levels have demonstrated good diagnostic sensitivity and specificity for the diagnosis of candidiasis in adult patients, but normal levels for children have not been established. We found higher 1,3-beta-D-glucan levels in children than those previously reported in adults.

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页码：924 / 925

页数：2

相关论文

共 12 条

[1] Neonatal candidemia and end-organ damage: A critical appraisal of the literature using meta-analytic techniques [J].

Benjamin, DK ;

Poole, C ;

Steinbach, WJ ;

Rowen, JL ;

Walsh, TJ .

PEDIATRICS, 2003, 112 (03) :634-640

[2] LYSIS CENTRIFUGATION BLOOD CULTURES IN THE DETECTION OF TISSUE-PROVEN INVASIVE CANDIDIASIS - DISSEMINATED VERSUS SINGLE-ORGAN INFECTION [J].

BERENGUER, J ;

BUCK, M ;

WITEBSKY, F ;

STOCK, F ;

PIZZO, PA ;

WALSH, TJ .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1993, 17 (02) :103-109

[3] Serum glucan levels are not specific for presence of fungal infections in intensive care unit patients [J].

Digby, J ;

Kalbfleisch, J ;

Glenn, A ;

Larsen, A ;

Browder, W ;

Williams, D .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2003, 10 (05) :882-885

[4] Nosocomial bloodstream infections in United States hospitals: A three-year analysis [J].

Edmond, MB ;

Wallace, SE ;

McClish, DK ;

Pfaller, MA ;

Jones, RN ;

Wenzel, RP .

CLINICAL INFECTIOUS DISEASES, 1999, 29 (02) :239-244

[5] Elevation of blood (1→3)-beta-D-glucan concentrations in hemodialysis patients [J].

Kato, A ;

Takita, T ;

Furuhashi, M ;

Takahashi, T ;

Maruyama, Y ;

Hishida, A .

NEPHRON, 2001, 89 (01) :15-19

[6] Comparative study of mortality and morbidity in premature infants (birth weight, <1,250 g) with candidemia or candidal meningitis [J].

Lee, BE ;

Cheung, PY ;

Robinson, JL ;

Evanochko, C ;

Robertson, CMT .

CLINICAL INFECTIOUS DISEASES, 1998, 27 (03) :559-565

[7]

Nakao A, 1997, HEPATO-GASTROENTEROL, V44, P1413

[8]

ODAHASI Z, 2004, CLIN INFECT DIS, V39, P199

[9] A NEW ENDOTOXIN SENSITIVE FACTOR ASSOCIATED WITH HEMOLYMPH COAGULATION SYSTEM OF HORSESHOE-CRAB (LIMULIDAE) [J].

OHKI, M ;

NAKAMURA, T ;

MORITA, T ;

IWANAGA, S .

FEBS LETTERS, 1980, 120 (02) :217-220

[10] Multicenter clinical evaluation of the (1→3) β-D-glucan assay as an aid to diagnosis of fungal infections in humans [J].

Ostrosky-Zeichner, L ;

Alexander, BD ;

Kett, DH ;

Vazquez, J ;

Pappas, PG ;

Saeki, F ;

Ketchum, PA ;

Wingard, J ;

Schiff, R ;

Tamura, H ;

Finkelman, MA ;

Rex, JH .

CLINICAL INFECTIOUS DISEASES, 2005, 41 (05) :654-659