Successful treatment of herpes simplex virus (HSV) recurrent genital infection with recombinant human (rh) granulocyte-macrophage colony stimulating factor (GM-CSF): A case report.

被引：6

作者：

Altamura, M

Geronimo, MG

Nappi, L

Ceci, O

Loizzi, P

Jirillo, E ^{[1
]}

机构：

[1] Policlin, Cattedra Immunol, I-70124 Bari, Italy

[2] Univ Bari, Fac Med & Chirurg, Clin Ostetr & Ginecol 2, Bari, Italy

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1997年 / 19卷 / 04期

关键词：

D O I：

10.3109/08923979709007665

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present work, we describe the treatment with rhGM-CSF of a woman affected by HSV recurrent genital infection and not responsive to specific antiviral therapy. The therapeutic regimen consisted of a subcutaneous administration of 300 mg\day of rhGM-CSF for six days. Before treatment with rhGM-CSF, polymorphonuclear cell and monocyte functional capacities and the antibacterial activity exerted by T cells were profoundly depressed. After treatment, a normalization of immune functions and a progressive disappearance of clinical manifestations were observed.

引用

页码：425 / 436

页数：12

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