Alkyl and alkoxycarbonyl derivatives of ginkgolide B: Synthesis and biological evaluation of PAF inhibitory activity

被引：42

作者：

Hu, LH

Chen, ZL ^{[1
]}

Xie, YY

Jiang, YY

Zhen, HW

机构：

[1] Acad Sinica, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China

[2] Second Mil Med Univ, Shanghai 200433, Peoples R China

[3] Navy 411 Hosp, Shanghai 200081, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0968-0896(00)00085-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alkyl and alkoxycarbonyl derivatives 6-24 of ginkgolide B, prepared in one step from ginkgolide B through alkylation and acylation and evaluated for their in vitro ability to inhibit the PAF-induced aggregation of rabbit platelets, show equivalent or superior activities to ginkgolide B. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1515 / 1521

页数：7

共 8 条

[1]

BENVENISTE J, 1979, CR ACAD SCI D NAT, V289, P1037

[2]

BRAQUET P, 1987, Drugs of the Future, V12, P643

[3]

BRAQUET P, 1987, PHARMACOL REV, V39, P97

[4] INTRAMOLECULAR AND INTERMOLECULAR HYDROXYL REACTIVITY DIFFERENCES IN GINKGOLIDE-A, GINKGOLIDE-B GINKGOLIDE-C AND THEIR CHEMICAL APPLICATIONS [J].