Lack of effect of oral selenite on p53 associated gene expression during TL01 therapy of psoriasis patients

被引:7
作者
DeSilva, Bernadette
Beckett, Geoffrey J.
McLean, Steven
Arthur, John R.
Hunter, John A. A.
Norval, Mary
McKenzie, Roddle C.
机构
[1] Univ Edinburgh, Sch Med, Dept Biomed Sci, Edinburgh EH8 9AG, Midlothian, Scotland
[2] Univ Edinburgh, Sch Med, Dept Clin Biochem, Edinburgh EH8 9AG, Midlothian, Scotland
[3] Univ Edinburgh, Sch Med, Dept Dermatol, Edinburgh EH8 9AG, Midlothian, Scotland
关键词
Langerhans cells; phototherapy; sodium selenite; sunburn cells; UV-induced proteins;
D O I
10.1111/j.1600-0781.2007.00277.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 [皮肤病与性病学];
摘要
Selenium (Se) has protective properties against ultraviolet (UV)-induced changes in skin cells in vitro but little is known about such activity in human subjects. In the present study, seven patients with psoriasis ingested 400 mu g of sodium selenite daily during a 4 week course of whole-body narrow-band UVB (TL01) therapy while six more psoriasis patients, similarly irradiated, ingested a placebo. Skin biopsies, collected at the start and end of the phototherapy were analysed for phosphorylated p53, Fas, Bcl-2, Bax and oxidized guaninosine, and for numbers of Langerhans and sunburn cells. Following the TL01 therapy, no significant difference was observed for any of these markers when the Se group was compared with the placebo group of patients, although p53 and Bcl-2 expression decreased in the Se supplemented group.
引用
收藏
页码:98 / 100
页数:3
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