In vitro study of ferromagnetic stents for implant assisted-magnetic drug targeting

被引：49

作者：

Aviles, Misael O.

Chen, Haitao

Ebner, Armin D.

Rosengart, Axel J.

Kaminski, Michael D.

Ritter, James A. ^{[1
]}

机构：

[1] Univ S Carolina, Dept Chem Engn, Columbia, SC 29208 USA

[2] Univ Chicago, Dept Neurol, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Surg Neurosurg, Chicago, IL 60637 USA

[4] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[5] Argonne Natl Lab, Div Chem Engn, Argonne, IL 60439 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

基金：

美国国家科学基金会;

关键词：

implant assisted-magnetic drug targeting; magnetic drug targeting; intravascular ferromagnetic stent; drug delivery; magnetic drug carrier particle; in vitro;

D O I：

10.1016/j.jmmm.2006.11.156

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Implant-assisted-magnetic drug targeting (IA-MDT) was studied in vitro using a coiled ferromagnetic wire stent made from stainless steel 430 or 304, and magnetic drug carrier particle (MDCP) surrogates composed of poly(styrene/divinyl benzene) embedded with 20 wt% magnetite. The fluid velocity, particle concentration, magnetic field strength, and stent material all proved to be important for capturing the MDCP surrogates. Overall, this in vitro study further confirmed the important role of the ferromagnetic implant for attracting and retaining MDCPs at the target zone. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：306 / 311

页数：6

共 25 条

[1] Magnetic drug targeting - Biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment [J].