Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety

被引：119

作者：

Chandrakantha, B. ^{[3
]}

Shetty, Prakash ^{[4
]}

Nambiyar, Vijesh ^{[1
]}

Isloor, Nishitha ^{[2
]}

Isloor, Arun M. ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Mangalore 575025, India

[2] Natl Inst Technol, Dept Chem Engn, Div Biotechnol, Mangalore 575025, India

[3] Syngene Int Ltd, Bangalore 560100, Karnataka, India

[4] Manipal Univ, Dept Printing & Media Engn, Manipal Inst Technol, Manipal 576104, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 03期

关键词：

1,3,4-Oxadiazole; Antibacterial study; Antifungal study; OXADIAZOLYL; DERIVATIVES; AGENTS;

D O I：

10.1016/j.ejmech.2009.11.046

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：1206 / 1210

页数：5

共 14 条

[1]

Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: Synthesis and their anti-inflammatory and analgesic activities [J].

Akhter, Mymoona ;

Husain, Asif ;

Azad, Bismillah ;

Ajmal, Mohd. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) :2372-2378

[2]

Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones [J].

Cao, S ;

Qian, XH ;

Song, GH ;

Chai, B ;

Jiang, ZS .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (01) :152-155

[3]

Synthesis, antimicrobial, and anti-HIV-1 activity of certain 5-(I-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminomethyl-1,3,4-oxadiazoline-2-thiones [J].

El-Emam, AA ;

Al-Deeb, OA ;

Al-Omar, M ;

Lehmann, J .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (19) :5107-5113

[4]

Farghaly AA, 2000, ARCH PHARM, V333, P53, DOI 10.1002/(SICI)1521-4184(200002)333:2/3<53::AID-ARDP53>3.0.CO

[5]

2-E

[6]

Furniss B.S., 1978, VOGELS TXB PRACTICAL, V4th, DOI DOI 10.1016/j.clinbiochem.2010.04.061

[7]

Kagthara PR, 1999, INDIAN J CHEM B, V38, P572

[8]

Khan MSY, 2001, INDIAN J HETEROCY CH, V11, P119

[9]

Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds [J].

Küçükgüzel, SG ;

Oruç, EE ;

Rollas, S ;

Sahin, F ;

Özbek, A .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (03) :197-206

[10]

Maslat AO, 2002, POL J PHARMACOL, V54, P55

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