CD40 antibody as an adjuvant induces enhanced T cell responses

被引：13

作者：

Carlring, J ^{[1
]}

Barr, TA ^{[1
]}

McCormick, AL ^{[1
]}

Health, AW ^{[1
]}

机构：

[1] Univ Sheffield, Sch Med, Div Genom Med, Sheffield S10 2RX, S Yorkshire, England

来源：

VACCINE | 2004年 / 22卷 / 25-26期

基金：

英国惠康基金;

关键词：

CD40; adjuvant; vaccine;

D O I：

10.1016/j.vaccine.2004.02.043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies against CD40, conjugated to antigen, act as potent immunological adjuvants for primary antibody responses. We show here that CD40mAbs can also act as strong adjuvants for memory antibody responses, and for T cell responses as measured by ex vivo T cell proliferation to antigen, and delayed type hypersensitivity. Interferon gamma secretion in response to antigen is also enhanced. Finally, the adjuvant effect of CD40mAbs for secondary antibody responses is transferred with T cells rather than B cells. CD40mAb apparently have potent adjuvant effects on both Th1-like cells, and on T cells able to promote B cell antibody production. It is possible that the adjuvant effects of CD40 are mediated at least in part, indirectly, through enhanced antigen presentation by specific B cells, to T cells. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3323 / 3328

页数：6

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