Depression in coronary artery disease: Novel pathophysiologic mechanisms and therapeutic implications

被引：56

作者：

Parissis, John T. ^{[1
]}

Fountoulaki, Katerina ^{[1
]}

Filippatos, Gerasimos ^{[1
]}

Adamopoulos, Stamatis ^{[1
]}

Paraskevaidis, Ioannis ^{[1
]}

Kremastinos, Dimitrios ^{[1
]}

机构：

[1] Attikon Univ Hosp, Dept Cardiol 2, Athens 15122, Greece

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 116卷 / 02期

关键词：

depression; coronary artery disease; antidepressants; prognosis;

D O I：

10.1016/j.ijcard.2006.03.038

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Depression is a common comorbid condition in patients with coronary artery disease and a well-documented risk factor for recurrent cardiac events and mortality. The exact mechanisms underlying the interplay between depression and ischernic heart disease remain poorly understood and the same is true for the most effective depression treatment for cardiac patients. This review summarizes current knowledge regarding the prognostic role of depression in patients with coronary artery disease, the pathophysiologic pathways involved, and the effects of antidepressant therapy on cardiovascular disease outcomes. With recent evidence suggesting that selective serotonin reuptake inhibitors may improve survival after myocardial intarction in patients with depression, diagnosis and treatment of this co-morbidity may be essential for the clinical management of coronary artery disease. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：153 / 160

页数：8

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