Engineered mesenchymal stem cells for cartilage repair

被引：55

作者：

Djouad, Farida

Mrugala, Dominique

Noel, Daniele

Jorgensen, Christian

机构：

[1] INSERM, U475, F-34197 Montpellier 5, France

[2] Univ Montpellier I, UFR Med, F-34000 Montpellier, France

[3] Hop Lapeyronie, Unite Clin Immunorhumatol, F-34295 Montpellier, France

来源：

REGENERATIVE MEDICINE | 2006年 / 1卷 / 04期

关键词：

bone marrow; chondrocyte; joint; stromal stem cell; treatment; AUTOLOGOUS CHONDROCYTE IMPLANTATION; FULL-THICKNESS DEFECTS; OSTEOCHONDRAL CYLINDER TRANSPLANTATION; ARTICULAR-CARTILAGE; CHONDROGENIC DIFFERENTIATION; IN-VITRO; BONE-MARROW; GENE-EXPRESSION; TRANSCRIPTION FACTOR; PERIOSTEAL GRAFTS;

D O I：

10.2217/17460751.1.4.529

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Healthy cartilage is a highly robust tissue, and is resilient against the stringent mechanical and biological contraints imposed upon it. Cartilage defects are common features of joint diseases, but current treatments can rarely restore the full function of native cartilage. Recent studies have provided new perspectives for cartilage engineering using mesenchymal stem cells (MSCs). However, the sequential events occurring during chondrogenesis must be fully understood before we are able to reproduce faithfully the complex molecular events that lead to MSC differentiation and long-term maintenance of cartilage characteristics. Here, we focus on the potential of MSCs to repair cartilage with an emphasis on the factors that are known to be required in inducing chondrogenesis.

引用

页码：529 / 537

页数：9

共 80 条

[1] The transcrintion factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 [J].