Key factors in mTOR regulation

被引：122

作者：

Bai, Xiaochun ^{[1
]}

Jiang, Yu ^{[2
]}

机构：

[1] So Med Univ, Sch Basic Med Sci, Dept Cell Biol, Guangzhou 510515, Guangdong, Peoples R China

[2] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 02期

关键词：

mTOR; TSC2; Rheb; FKBP38; PRAS40; hVps34; Rag GTPases; Phosphatidic acid; P70; S6; KINASE; RICH AKT SUBSTRATE; TUMOR-SUPPRESSOR COMPLEX; GTP-BINDING PROTEINS; MAMMALIAN-CELL SIZE; 40 KDA PRAS40; NF-KAPPA-B; TUBEROUS SCLEROSIS; AMINO-ACID; RAPAMYCIN MTOR;

D O I：

10.1007/s00018-009-0163-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that controls a wide range of growth-related cellular processes. In the past several years, many factors have been identified that are involved in controlling mTOR activity. Those factors in turn are regulated by diverse signaling cascades responsive to changes in intracellular and environmental conditions. The molecular connections between mTOR and its regulators form a complex signaling network that governs cellular metabolism, growth and proliferation. In this review, we discuss some key factors in mTOR regulation and mechanisms by which these factors control mTOR activity.

引用

页码：239 / 253

页数：15

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