Fetal cell carcinogenesis of the thyroid: Theory and practice

被引：48

作者：

Takano, Toru ^{[1
]}

机构：

[1] Osaka Univ, Dept Lab Med, Grad Sch Med, Suita, Osaka 5650871, Japan

来源：

SEMINARS IN CANCER BIOLOGY | 2007年 / 17卷 / 03期

关键词：

neoplasms; stem cells; thyroid gland; gene expression; fetal cell research;

D O I：

10.1016/j.semcancer.2006.02.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A novel hypothesis of thyroid carcinogenesis, the "fetal cell carcinogenesis" hypothesis, in which cancer cells are derived from the remnants of three types of fetal thyroid cells, instead of normal thyroid follicular cells, is proposed. In this hypothesis, thyroid cancer cells are generated from fetal cells by proliferation without differentiation and oncogenes play an oncogenic role by preventing fetal cells from differentiating. This hypothesis explains well the clinical and biological features and recent molecular evidence of thyroid carcinoma. It underscores the importance of clarifying the molecular mechanism of thyroid development and the identification of fetal thyroid cells, especially thyroid stem cells (TSCs), since such data will lead to better understanding of thyroid carcinoma and other thyroid diseases. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：233 / 240

页数：8

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