Small but mighty timekeepers

被引：6

作者：

Adoutte, A ^{[1
]}

机构：

[1] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

来源：

NATURE | 2000年 / 408卷 / 6808期

关键词：

D O I：

10.1038/35040669

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A tiny RNA molecule ensures that the larvae of a roundworm develop into adults. The discovery of this RNA in many other animal groups implies that this way of keeping developmental time may be universal.

引用

页码：37 / 38

页数：2

共 5 条

[1] Control of developmental timing in Caenorhabditis elegans [J].

Ambros, V .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (04) :428-433

[2] Noncoding RNA genes [J].

Eddy, SR .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (06) :695-699

[3] Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA [J].

Pasquinelli, AE ;

Reinhart, BJ ;

Slack, F ;

Martindale, MQ ;

Kuroda, MI ;

Maller, B ;

Hayward, DC ;

Ball, EE ;

Degnan, B ;

Müller, P ;

Spring, J ;

Srinivasan, A ;

Fishman, M ;

Finnerty, J ;

Corbo, J ;

Levine, M ;

Leahy, P ;

Davidson, E ;

Ruvkun, G .

NATURE, 2000, 408 (6808) :86-89

[4] The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J].

Reinhart, BJ ;

Slack, FJ ;

Basson, M ;

Pasquinelli, AE ;

Bettinger, JC ;

Rougvie, AE ;

Horvitz, HR ;

Ruvkun, G .

NATURE, 2000, 403 (6772) :901-906

[5] The lin-41 RBCC gene acts in the C-elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor [J].

Slack, FJ ;

Basson, M ;

Liu, ZC ;

Ambros, V ;

Horvitz, HR ;

Ruvkun, G .

MOLECULAR CELL, 2000, 5 (04) :659-669

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