A polygenic basis for late-onset disease

被引：109

作者：

Wright, A

Charlesworth, B

Rudan, I

Carothers, A

Campbell, H

机构：

[1] Western Gen Hosp, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland

[3] Univ Edinburgh, Dept Publ Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland

[4] Univ Zagreb, Sch Med, Dept Epidemiol, Zagreb 41001, Croatia

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0168-9525(02)00033-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The biological basis of late-onset disease has been shaped by genetic factors subject to varying degrees of evolutionary constraint. Late-onset traits are not only more sensitive to environmental variation, owing to the breakdown of homeostatic mechanisms, but they also show higher levels of genetic variation than traits directly influencing reproductive fitness. The origin and nature of this variation suggests that current strategies are poorly suited to identifying genes involved in many complex diseases.

引用

页码：97 / 106

页数：10

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[1] Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: Fasting serum-insulin level in the hutterites [J].