Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats

被引：16

作者：

Ishikawa, Takashi ^{[1
]}

Takechi, Kenshi ^{[1
]}

Rahman, Ashequr ^{[1
]}

Ago, Jun ^{[1
]}

Matsumoto, Naotaka ^{[1
]}

Murakami, Aya ^{[1
]}

Kamei, Chiaki ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Med Pharmacol, Okayama 7008530, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 03期

关键词：

maximal electroshock; tonic extensor seizure; electroencephalogram seizure; epinastine; fexofenadine; infant rat;

D O I：

10.1248/bpb.30.477

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The influences of histamine H-1 receptor antagonists on maximal electroshock seizure were studied using infant rats. In this study, electroconvulsion was induced by stimulating rats using ear-clip electrodes, and the durations of electroencephalogram (EEG) seizure, tonic extensor (TE) seizure and clonic (CL) seizure induced by maximal electroshock were measured. Diphenhydramine, chlorpheniramine, cyproheptadine and ketotifen caused a dose-dependent and significant prolongation of both EEG seizure and TE seizure induced by maximal electroshock. On the other hand, epinastine and fexofenadine caused no such effects, even at a dose of 50 mg/kg. All drugs used in this study showed no significant effect on CL seizure induced by maximal electroshock. From these findings, it is suggested that epinastine and fexofenadine may cause no harmful influence on epilepsy, even when used in a little child.

引用

页码：477 / 480

页数：4

共 22 条

[1]

Sedation and performance impairment of diphenhydramine and second-generation antihistamines: A meta-analysis [J].