The Architecture and Evolution of Cancer Neochromosomes

被引：128

作者：

Garsed, Dale W. ^{[1
,9
,10
]}

Marshall, Owen J. ^{[5
,6
]}

Corbin, Vincent D. A. ^{[1
,2
,3
]}

Hsu, Arthur ^{[2
]}

Di Stefano, Leon ^{[2
]}

Schroeder, Jan ^{[2
,3
]}

Li, Jason ^{[1
]}

Feng, Zhi-Ping ^{[2
,3
]}

Kim, Bo W. ^{[5
,6
]}

Kowarsky, Mark ^{[2
]}

Lansdell, Ben ^{[2
]}

Brookwell, Ross ^{[7
]}

Myklebost, Ola ^{[11
]}

Meza-Zepeda, Leonardo ^{[11
]}

Holloway, Andrew J. ^{[1
]}

Pedeutour, Florence ^{[8
]}

Choo, K. H. Andy ^{[5
,6
]}

Damore, Michael A. ^{[12
]}

Deans, Andrew J. ^{[13
]}

Papenfuss, Anthony T. ^{[1
,2
,3
,4
,9
]}

Thomas, David M. ^{[1
,9
,14
]}

机构：

[1] Peter MacCallum Canc Ctr, East Melbourne, Vic 3002, Australia

[2] Walter & Eliza Hall Inst Med Res, Bioinformat Div, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia

[4] Univ Melbourne, Dept Math & Stat, Melbourne, Vic 3010, Australia

[5] Univ Melbourne, Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[6] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Parkville, Vic 3052, Australia

[7] Sullivan Nicolaides Pathol, Indooroopilly, Qld 4068, Australia

[8] Nice Univ Hosp, Lab Solid Tumors Genet, F-06107 Nice, France

[9] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia

[10] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia

[11] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Tumor Biol, N-0424 Oslo, Norway

[12] Amgen Inc, Thousand Oaks, CA 91320 USA

[13] St Vincents Inst, Fitzroy, Vic 3065, Australia

[14] Garvan Inst Med Res, Kinghorn Canc Ctr, Sydney, NSW 2010, Australia

来源：

CANCER CELL | 2014年 / 26卷 / 05期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

WELL-DIFFERENTIATED LIPOSARCOMA; GENOMIC REARRANGEMENT; MARKER CHROMOSOMES; HIGH-RESOLUTION; DNA-DAMAGE; AMPLIFICATION; AMPLICONS; SEQUENCE; MDM2; OVEREXPRESSION;

D O I：

10.1016/j.ccell.2014.09.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well-and/or dedifferentiated liposarcomas. Neochromosomes, which can exceed 600 Mb in size, initially arise as circular structures following chromothripsis involving chromosome 12. The core of the neochromosome is amplified, rearranged, and corroded through hundreds of breakage-fusion-bridge cycles. Under selective pressure, amplified oncogenes are overexpressed, while coamplified passenger genes may be silenced epigenetically. New material may be captured during punctuated chromothriptic events. Centromeric corrosion leads to crisis, which is resolved through neocentromere formation or native centromere capture. Finally, amplification terminates, and the neochromosome core is stabilized in linear form by telomere capture. This study investigates the dynamic mutational processes underlying the life history of a special form of cancer mutation.

引用

页码：653 / 667

页数：15

共 42 条

[1] Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer [J].

Agudo, D ;

Gómez-Esquer, F ;

Martínez-Arribas, F ;

Núñez-Villar, MJ ;

Pollán, M ;

Schneider, J .

INTERNATIONAL JOURNAL OF CANCER, 2004, 109 (05) :717-720

[2] The organization and function of chromosomes - Workshop on chromosome structural elements: from DNA sequence to function [J].

Baird, DM ;

Farr, CJ .

EMBO REPORTS, 2006, 7 (04) :372-376

[3] Depletion of a single nucleoporin, Nup107, induces apoptosis in eukaryotic cells [J].

Banerjee, Hirendra Nath ;

Gibbs, Jaqluene ;

Jordan, Tiffany ;

Blackshear, Millon .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2010, 343 (1-2) :21-25

[4] Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy [J].

Barretina, Jordi ;

Taylor, Barry S. ;

Banerji, Shantanu ;

Ramos, Alexis H. ;

Lagos-Quintana, Mariana ;

DeCarolis, Penelope L. ;

Shah, Kinjal ;

Socci, Nicholas D. ;

Weir, Barbara A. ;

Ho, Alan ;

Chiang, Derek Y. ;

Reva, Boris ;

Mermel, Craig H. ;

Getz, Gad ;

Antipin, Yevgenyi ;

Beroukhim, Rameen ;

Major, John E. ;

Hatton, Charles ;

Nicoletti, Richard ;

Hanna, Megan ;

Sharpe, Ted ;

Fennell, Tim J. ;

Cibulskis, Kristian ;

Onofrio, Robert C. ;

Saito, Tsuyoshi ;

Shukla, Neerav ;

Lau, Christopher ;

Nelander, Sven ;

Silver, Serena J. ;

Sougnez, Carrie ;

Viale, Agnes ;

Winckler, Wendy ;

Maki, Robert G. ;

Garraway, Levi A. ;

Lash, Alex ;

Greulich, Heidi ;

Root, David E. ;

Sellers, William R. ;

Schwartz, Gary K. ;

Antonescu, Cristina R. ;

Lander, Eric S. ;

Varmus, Harold E. ;

Ladanyi, Marc ;

Sander, Chris ;

Meyerson, Matthew ;

Singer, Samuel .

NATURE GENETICS, 2010, 42 (08) :715-U103

[5] Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution [J].

Bignell, Graham R. ;

Santarius, Thomas ;

Pole, Jessica C. M. ;

Butler, Adam P. ;

Perry, Janet ;

Pleasance, Erin ;

Greenman, Chris ;

Menzies, Andrew ;

Taylor, Sheila ;

Edkins, Sarah ;

Campbell, Peter ;

Quail, Michael ;

Plumb, Bob ;

Matthews, Lucy ;

Mclay, Kirsten ;

Edwards, Paul A. W. ;

Rogers, Jane ;

Wooster, Richard ;

Futreal, P. Andrew ;

Stratton, Michael R. .

GENOME RESEARCH, 2007, 17 (09) :1296-1303

[6] DOUBLE-MINUTE CHROMOSOMES IN PLASTIC FILM-INDUCED SARCOMAS IN MICE [J].

BUOEN, LC ;

BRAND, KG .

NATURWISSENSCHAFTEN, 1968, 55 (03) :135-+

[7] MOLECULAR ANALYSIS AND CHROMOSOMAL MAPPING OF AMPLIFIED GENES ISOLATED FROM A TRANSFORMED MOUSE 3T3-CELL LINE [J].

CAHILLYSNYDER, L ;

YANGFENG, T ;

FRANCKE, U ;

GEORGE, DL .

SOMATIC CELL AND MOLECULAR GENETICS, 1987, 13 (03) :235-244

[8] Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases [J].

Forus, A ;

Larramendy, ML ;

Meza-Zepeda, LA ;

Bjerkehagen, B ;

Godager, LH ;

Dahlberg, AB ;

Saeter, G ;

Knuutila, S .

CANCER GENETICS AND CYTOGENETICS, 2001, 125 (02) :100-111

[9] Cancer-associated neochromosomes: a novel mechanism of oncogenesis [J].

Garsed, Dale W. ;

Holloway, Andrew J. ;

Thomas, David M. .

BIOESSAYS, 2009, 31 (11) :1191-1200

[10] HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon [J].

Italiano, Antoine ;

Bianchini, Laurence ;

Keslair, Frederique ;

Bonnafous, Stephanie ;

Cardot-Leccia, Nathalie ;

Coindre, Jean-Michel ;

Dumollard, Jean-Marc ;

Hofman, Paul ;

Leroux, Agnes ;

Mainguene, Claire ;

Peyrottes, Isabelle ;

Ranchere-Vince, Dominique ;

Terrier, Philippe ;

Tran, Albert ;

Gual, Philippe ;

Pedeutour, Florence .

INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (10) :2233-2241

← 1 2 3 4 5 →