Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans

被引：59

作者：

Akhoon, Bashir Akhlaq ^{[1
]}

Pandey, Swapnil ^{[1
]}

Tiwari, Sudeep ^{[1
]}

Pandey, Rakesh ^{[1
]}

机构：

[1] CSIR Cent Inst Med & Aromat Plants, Microbial Technol & Nematol Dept, Lucknow 226015, Uttar Pradesh, India

来源：

EXPERIMENTAL GERONTOLOGY | 2016年 / 78卷

关键词：

Withanolide A; Aging; Neuroprotection; Insulin/IGF-1; pathway; Caenorhabditis elegans; CALORIC RESTRICTION; ALZHEIMERS-DISEASE; PROTEIN-STRUCTURE; SPAN EXTENSION; LONGEVITY; INSULIN; SKN-1; EXPRESSION; MUTATIONS; IDENTIFICATION;

D O I：

10.1016/j.exger.2016.03.004

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Withanolide A (steroidal lactone) forms the major constituent of the most popular herbal drug in Ayurvedic medicine, Ashwagandha. It has been used since ancient times as an alternative medicine for the treatment of a variety of age related disorders. Here we provide multiple lines of evidence indicating that Withanolide A improves healthspan, delays age-associated physiological changes and also extends the lifespan of Caenorhabditis elegans. We also report several neuroprotective benefits of this natural product, including its antiamyloidogenic effects, alleviation of alpha-synuclein aggregation and neuroprotection through modulation of neural mediators like acetylcholine. We observed that Withanolide A mediates lifespan extension and promotes stress resistance via insulin/insulin-like growth factor signaling pathway. Such findings could be helpful to develop a therapeutic medicine from this natural product for the prevention or reversal of age-related ailments and to improve the survival of patients suffering from Alzheimer's or Parkinson's disease. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：47 / 56

页数：10

共 73 条

[1]

Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans [J].