The multiple functions of Numb

被引：162

作者：

Gulino, Alberto ^{[1
,2
]}

Di Marcotullio, Lucia ^{[1
]}

Screpanti, Isabella ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Expt Med, I-00161 Rome, Italy

[2] Neuromed Inst, Pozzilli, Italy

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 06期

关键词：

Numb; Stem cell; Cell fate; Asymmetric cell division; AMYLOID PRECURSOR PROTEIN; ASYMMETRIC CELL-DIVISION; FATE DETERMINANT NUMB; MAMMALIAN NUMB; SELF-RENEWAL; MOUSE NUMB; TUMOR-SUPPRESSOR; FAMILY-PROTEINS; STEM-CELLS; NOTCH;

D O I：

10.1016/j.yexcr.2009.11.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Numb is an evolutionary conserved protein that plays critical roles in cell fate determination. Mammalian Numb displays a higher degree of structural complexity compared to the Drosophila homolog based on the number of encoding genes (Numb and Numb-like) and of alternative spliced isoforms. Accordingly, Numb proteins display a complex pattern of functions such as the control of asymmetric cell division and cell fate choice, endocytosis, cell adhesion, cell migration, ubiquitination of specific substrates and a number of signaling pathways (i.e. Notch, Hedgehog, p53). Recent findings indicate that, besides controlling such physiologic developmental processes, subversion of the above Numb-dependent events plays a critical role in disease (e.g. cancer). We will review here the multiple functions of mNumb and their underlying molecular mechanisms in development and disease. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：900 / 906

页数：7

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