Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents

被引：49

作者：

Cho, WJ ^{[1
]}

Park, MJ

Chung, BH

Lee, CO

机构：

[1] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

[2] Korea Res Inst Chem Technol, Screening Ctr, Daejeon, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10190-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To investigate the structure-activity relationship of 7,8-dimethoxy-2-methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H)-one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：41 / 46

页数：6

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