β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia

被引：192

作者：

Bourgeat, P. ^{[1
]}

Chetelat, G. ^{[2
,3
,4
]}

Villemagne, V. L. ^{[2
,3
,5
,7
]}

Fripp, J. ^{[1
]}

Raniga, P. ^{[1
]}

Pike, K. ^{[2
,3
,5
]}

Acosta, O. ^{[1
]}

Szoeke, C. ^{[1
]}

Ourselin, S. ^{[8
]}

Ames, D. ^{[9
]}

Ellis, K. A. ^{[10
]}

Martins, R. N. ^{[11
]}

Masters, C. L. ^{[5
,6
]}

Rowe, C. C. ^{[2
,3
,7
]}

Salvado, O. ^{[1
]}

Grp, A. I. B. L. Res

机构：

[1] Royal Brisbane & Womens Hosp, Australian e Hlth Res Ctr, CSIRO Preventat Hlth Natl Res Flagship ICTC, BioMedIA, Herston, Qld 4029, Australia

[2] Austin Hlth, Dept Nucl Med, Melbourne, Vic, Australia

[3] Austin Hlth, Ctr PET, Melbourne, Vic, Australia

[4] Univ Caen Basse Normandie, INSERM, EPHE, CHU Cote Nacre,Unite U923,GIP Cyceron, Caen, France

[5] Univ Melbourne, Mental Hlth Res Inst, Melbourne, Vic 3010, Australia

[6] Univ Melbourne, Ctr Neurosci, Melbourne, Vic 3010, Australia

[7] Univ Melbourne, Dept Med, Melbourne, Vic 3010, Australia

[8] UCL, Ctr Med Image Comp, London WC1E 6BT, England

[9] Natl Ageing Res Inst, Melbourne, Vic, Australia

[10] Univ Melbourne, Acad Unit Psychiat Old Age, Dept Psychiat, St Georges Hosp,St Vincents Aged Psychiat Serv, Melbourne, Vic 3010, Australia

[11] Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Exercise Biomed & Hlth Sci, Joondalup, WA, Australia

来源：

NEUROLOGY | 2010年 / 74卷 / 02期

基金：

英国医学研究理事会;

关键词：

MILD COGNITIVE IMPAIRMENT; PRECLINICAL ALZHEIMERS-DISEASE; NONDEMENTED INDIVIDUALS; BRAIN; MRI; PIB; DEPOSITION; MEMORY; VOLUME; PET;

D O I：

10.1212/WNL.0b013e3181c918b5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: To investigate whether global and regional beta-amyloid (A beta) burden as measured with C-11 Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD). Methods: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using C-11-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group. Results: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group. Conclusions: The strong correlation between hippocampal atrophy and beta-amyloid (A beta) burden in the Pittsburgh compound B-positive healthy control group suggests that A beta deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration. Neurology (R) 2010;74:121-127

引用

页码：121 / 127

页数：7

共 41 条

[1]

Automated voxel-based 3D cortical thickness measurement in a combined Lagrangian-Eulerian PDE approach using partial volume maps [J].

Acosta, Oscar ;

Bourgeat, Pierrick ;

Zuluaga, Maria A. ;

Fripp, Jurgen ;

Salvado, Olivier ;

Ourselin, Sebastien .

MEDICAL IMAGE ANALYSIS, 2009, 13 (05) :730-743

[2]

Multi-atlas based segmentation of brain images: Atlas selection and its effect on accuracy [J].

Aljabar, P. ;

Heckemann, R. A. ;

Hammers, A. ;

Hajnal, J. V. ;

Rueckert, D. .

NEUROIMAGE, 2009, 46 (03) :726-738

[3]

In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease [J].

Baron, JC ;

Chételat, G ;

Desgranges, B ;

Perchey, G ;

Landeau, B ;

de la Sayette, V ;

Eustache, F .

NEUROIMAGE, 2001, 14 (02) :298-309

[4]

Trajectories of brain loss in aging and the development of cognitive impairment [J].

Carlson, N. E. ;

Moore, M. M. ;

Dame, A. ;

Howieson, D. ;

Silbert, L. C. ;

Quinn, J. F. ;

Kaye, J. A. .

NEUROLOGY, 2008, 70 (11) :828-833

[5]

Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study [J].

Chan, D ;

Janssen, JC ;

Whitwell, JL ;

Watt, HC ;

Jenkins, R ;

Frost, C ;

Rossor, MN ;

Fox, NC .

LANCET, 2003, 362 (9390) :1121-1122

[6]

Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging [J].

Chetelat, G ;

Baron, JC .

NEUROIMAGE, 2003, 18 (02) :525-541

[7]

Delis D.C., 2000, CVLT 2 CALIFORNIA VE

[8]

The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease [J].

Ellis, Kathryn A. ;

Bush, Ashley I. ;

Darby, David ;

De Fazio, Daniela ;

Foster, Jonathan ;

Hudson, Peter ;

Lautenschlager, Nicola I. ;

Lenzo, Nat ;

Martins, Ralph N. ;

Maruff, Paul ;

Masters, Colin ;

Milner, Andrew ;

Pike, Kerryn ;

Rowe, Christopher ;

Savage, Greg ;

Szoeke, Cassandra ;

Taddei, Kevin ;

Villemagne, Victor ;

Woodward, Michael ;

Ames, David .

INTERNATIONAL PSYCHOGERIATRICS, 2009, 21 (04) :672-687

[9]

Decreased Cerebrospinal Fluid Aβ42 Correlates with Brain Atrophy in Cognitively Normal Elderly [J].

Fagan, Anne M. ;

Head, Denise ;

Shah, Aarti R. ;

Marcus, Daniel ;

Mintun, Mark ;

Morris, John C. ;

Holtzman, David M. .

ANNALS OF NEUROLOGY, 2009, 65 (02) :176-183

[10]

Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment [J].

Fleisher, A. S. ;

Sun, S. ;

Taylor, C. ;

Ward, C. P. ;

Gamst, A. C. ;

Petersen, R. C. ;

Jack, C. R., Jr. ;

Aisen, P. S. ;

Thal, L. J. .

NEUROLOGY, 2008, 70 (03) :191-199

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