Therapies for Musculoskeletal Disease: Can we Treat Two Birds with One Stone?

被引：105

作者：

Girgis, Christian M. ^{[1
,3
]}

Mokbel, Nancy ^{[1
]}

DiGirolamo, Douglas J. ^{[2
]}

机构：

[1] Garvan Inst Med Res, Sydney, NSW, Australia

[2] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD USA

[3] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia

来源：

CURRENT OSTEOPOROSIS REPORTS | 2014年 / 12卷 / 02期

关键词：

Muscle; Bone; Anabolic agents; Osteoporosis; Sarcopenia; BONE-MINERAL DENSITY; VITAMIN-D-RECEPTOR; GROWTH-FACTOR-I; SKELETAL-MUSCLE MASS; ANDROGEN RECEPTOR; BODY-COMPOSITION; PHYSICAL FUNCTION; D SUPPLEMENTATION; DIETARY-PROTEIN; DOUBLE-BLIND;

D O I：

10.1007/s11914-014-0204-5

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Musculoskeletal diseases are highly prevalent with staggering annual health care costs across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis)-both in normal aging and pathologic states-can lead to vastly compounded risk for fracture in patients. Until now, our therapeutic approach to the prevention of such fractures has focused solely on bone, but our increasing understanding of the interconnected biology of muscle and bone has begun to shift our treatment paradigm for musculoskeletal disease. Targeting pathways that centrally regulate both bone and muscle (eg, GH/IGF-1, sex steroids, etc.) and newly emerging pathways that might facilitate communication between these 2 tissues (eg, activin/myostatin) might allow a greater therapeutic benefit and/or previously unanticipated means by which to treat these frail patients and prevent fracture. In this review, we will discuss a number of therapies currently under development that aim to treat musculoskeletal disease in precisely such a holistic fashion.

引用

页码：142 / 153

页数：12

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