Idiopathic pulmonary fibrosis: new insights into pathogenesis

被引：94

作者：

Noble, PW

Homer, RJ

机构：

[1] Yale Univ, Sch Med, Pulm & Crit Care Med Sect, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06520 USA

来源：

CLINICS IN CHEST MEDICINE | 2004年 / 25卷 / 04期

关键词：

D O I：

10.1016/j.ccm.2004.04.003

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The combination of the unique pathologic features of usual interstitial pneumonia (UIP) on biopsy, the progressive clinical course, and resistance to anti-inflammatory therapy constitutes the cardinal manifestations of what is termed idiopathic pulmonary fibrosis (IPF)/UIP, and it has led to recent suggestions that new therapies should be directed at regulating fibroblast functions rather than targeting the inflammatory response. The observation that "early" UIP looks like "late" UIP but there is less of it has been largely responsible for re-evaluation of the paradigm that IPF is the result of uncontrolled lung inflammation. This article highlights aspects of current thoughts on pathogenesis of IPF and expands on recent reviews.

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页码：749 / +

页数：11

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