SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci

被引：2067

作者：

Shi, YY

He, L

机构：

[1] Shanghai Jiao Tong Univ, Bio X Ctr, NHGG, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Bio X Llife Sci Res Ctr, Shanghai, Peoples R China

来源：

CELL RESEARCH | 2005年 / 15卷 / 02期

关键词：

software; linkage disequilibrium; haplotype analysis; genetic association study;

D O I：

10.1038/sj.cr.7290272

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses of linkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large number of samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data, we developed a robust and user-friendly software platform with a series of tools for analysis in association study with high efficiency. The platform has been well evaluated by several sets of real data.

引用

页码：97 / 98

页数：2

共 6 条

[1] Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8 [J].

Chen, WY ;

Shi, YY ;

Zheng, YL ;

Zhao, XZ ;

Zhang, GJ ;

Chen, SQ ;

Yang, PD ;

He, L .

HUMAN MOLECULAR GENETICS, 2004, 13 (23) :2991-2995

[2] No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene (GRIA4) and schizophrenia in the Chinese population [J].

Guo, SZ ;

Shi, YY ;

Zhao, XZ ;

Duan, SW ;

Zhou, J ;

Meng, JW ;

Yang, YF ;

Gu, NF ;

Feng, GY ;

Liu, HJ ;

Zhu, SM ;

He, L .

NEUROSCIENCE LETTERS, 2004, 369 (02) :168-172

[3]

LEWONTIN RC, 1988, GENETICS, V120, P849

[4] Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population [J].

Shi, YY ;

Zhao, XZ ;

Yu, L ;

Tao, R ;

Tang, JX ;

La, YJ ;

Duan, Y ;

Gao, B ;

Gu, NF ;

Xu, YF ;

Feng, GY ;

Zhu, SM ;

Liu, HJ ;

Salter, H ;

He, L .

GENOME RESEARCH, 2004, 14 (07) :1345-1349

[5] Evidence for association between single nucleotide polymorphisms in T complex protein 1 gene and schizophrenia in the Chinese Han population [J].

Yang, MS ;

Yu, L ;

Guo, TW ;

Zhu, SM ;

Liu, HJ ;

Shi, YY ;

Gu, NF ;

Feng, GY ;

He, L .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (05)

[6] A case control and family based association study of the neuregulin1 gene and schizophrenia [J].

Zhao, X ;

Shi, Y ;

Tang, J ;

Tang, R ;

Yu, L ;

Gu, N ;

Feng, G ;

Zhu, S ;

Liu, H ;

Xing, Y ;

Zhao, S ;

Sang, H ;

Guan, Y ;

St Clair, D ;

He, L .

JOURNAL OF MEDICAL GENETICS, 2004, 41 (01) :31-34

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