Cholinesterase inhibiting withanolides from Withania somnifera

被引：75

作者：

Choudhary, MI ^{[1
]}

Yousuf, S ^{[1
]}

Nawaz, SA ^{[1
]}

Ahmed, S ^{[1
]}

Atta-ur-Rahman ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 11期

关键词：

Withania somnifera; Solanaceae; withanolide; withaferin A; acetylcholinesterase inhibition; butyrylcholinesterase inhibition;

D O I：

10.1248/cpb.52.1358

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A total of two new (1, 2) and four known (3-6) withanolides were isolated from the whole plant of Withania somnifera. Their structures were elucidated on the basis of spectroscopic techniques and were characterized as 6alpha,7alpha-epoxy-3beta,5alpha,20beta-trihydroxy-1-oxowitha-24-enolide (1), 5beta,6beta-epoxy-4beta,17alpha27-trihydroxy-1-oxowitha-2,24-dienolide (2), withaferin-A (3), 2,3-dihydrowithaferin-A (4), 6alpha,70alpha-epoxy-5alpha20beta-dihydroxy-1-oxowitha-2,24-dienolide (5), and 5beta,6beta-epoxy-4beta-hydroxy-1-oxowitha-2,14,24-trienolide (6), respectively. Compounds 2, 3, 5, and 6 displayed inhibitory potential against butyrylcholinesterase, but only compounds 3, 4, and 6 were found to be active against acetylcholinesterase.

引用

页码：1358 / 1361

页数：4

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