Establishment of a normal reference value of parathyroid hormone in a large healthy Chinese population and evaluation of its relation to bone turnover and bone mineral density

被引：87

作者：

Li, M. ^{[1
]}

Lv, F. ^{[1
]}

Zhang, Z. ^{[2
]}

Deng, W. ^{[3
]}

Li, Y. ^{[4
]}

Deng, Z. ^{[5
]}

Jiang, Y. ^{[1
]}

Wang, O. ^{[1
]}

Xing, X. ^{[1
]}

Xu, L. ^{[6
]}

Xia, W. ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Dept Endocrinol, Key Lab Endocrinol, Minist Hlth,Peking Union Med Coll Hosp,Peking Uni, 1 Shuaifuyuan,Wangfujing St, Beijing 100730, Peoples R China

[2] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Osteoporosis, 600 Yishan Rd, Shanghai 200233, Peoples R China

[3] Gen Hosp Guangzhou Mil Command, Dept Geriatr, 111 Liuhua Rd, Guangzhou 510010, Guangdong, Peoples R China

[4] Hubei Gen Hosp, Dept Lab, 238 Jiefang Rd, Wuhan 430060, Peoples R China

[5] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China

[6] Chinese Acad Med Sci, Dept Obstet & Gynecol, Peking Union Med Coll, Peking Union Med Coll Hosp, 1 Shuaifuyuan,Wangfujing St, Beijing 100730, Peoples R China

来源：

OSTEOPOROSIS INTERNATIONAL | 2016年 / 27卷 / 05期

基金：

中国国家自然科学基金;

关键词：

25OHD; BMD; Bone turnover; P1NP; PTH; beta-CTX; VITAMIN-D STATUS; AFRICAN-AMERICAN WOMEN; PRIMARY HYPERPARATHYROIDISM; POSTMENOPAUSAL WOMEN; CALCIUM-ABSORPTION; VERTEBRAL FRACTURES; D SUPPLEMENTATION; D DEFICIENCY; PLASMA PTH; D-RECEPTOR;

D O I：

10.1007/s00198-015-3475-5

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

A normal reference value of parathyroid hormone (PTH) was established for the first time in a large sample of healthy Chinese subjects by completely excluding interference of vitamin D deficiency. A high PTH level correlated significantly with an elevated bone turnover and a reduced bone mineral density (BMD). The aims of this study are to establish a normal reference value for serum PTH and to evaluate the effect of parathyroid gland status on bone turnover and BMD. Our cross-sectional study included 1436 healthy individuals from 5 different Chinese cities. Concentrations of serum PTH, 25-hydroxyvitamin D (25OHD), procollagen I N-terminal peptide (P1NP, a bone formation marker), and carboxyl-terminal telopeptide of type I collagen (beta-CTX, a bone resorption marker) were measured by electrochemiluminescence immunoassay. BMD was measured by dual-energy X-ray absorptiometry. The relation of PTH concentration to age, gender, height, and weight was examined. Reference values of PTH were established for all subjects and for subjects categorized by serum 25OHD concentrations. Correlations of PTH levels with bone turnover biomarkers and BMD were statistically analyzed. Reference values of PTH were 8.84-69.95 pg/mL in all the subjects and 7.48-60.73 and 5.83-56.78 pg/mL in the subjects with serum 25OHD concentrations of a parts per thousand yen20 and a parts per thousand yen30 ng/mL, respectively. Serum PTH showed a negative linear correlation with 25OHD, and the breakpoint was 18.21 ng/mL, below which the PTH level rapidly increased. The increase in PTH levels with age showed a positive linear correlation with P1NP and beta-CTX concentrations and a negative linear correlation with BMD at the lumbar spines and the femoral neck. A reference value of PTH was established in a large sample of healthy Chinese subjects according to 25OHD status, gender, and age. A high PTH level correlated significantly with an elevated bone turnover and a reduced BMD.

引用

页码：1907 / 1916

页数：10

共 41 条

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Optimal vitamin D status and serum parathyroid hormone concentrations in African American women [J].