Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

被引：74

作者：

Arshad, S. Hasan ^{[1
]}

机构：

[1] Univ Southampton, Infect Inflammat & Immun Res Div, Sch Med, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2010年 / 10卷 / 01期

基金：

英国医学研究理事会;

关键词：

Asthma; Allergen; Prevention; Environment; Allergy; Atopy; HOUSE-DUST MITE; RISK-FACTORS; INNER-CITY; EARLY-LIFE; BRONCHIAL HYPERRESPONSIVENESS; RESPIRATORY SYMPTOMS; ENDOTOXIN EXPOSURE; COCKROACH ALLERGEN; CHILDHOOD ASTHMA; CAT ALLERGENS;

D O I：

10.1007/s11882-009-0082-6

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Common indoor allergens include house dust mite, cockroach, animal dander, and certain molds. In genetically susceptible children, exposure to these indoor allergens during the critical postnatal period may lead to sensitization in early childhood. Consistent evidence indicates that children sensitized to common indoor allergens are at several-fold higher risk of asthma and allergy. Due to conflicting evidence from prospective studies, some doubt remains regarding a direct and dose-response relationship between exposure and development of asthma. However, in recent years, evidence has accumulated that exposure to indoor allergen causes asthma and allergy, but this effect may depend on dose and type of allergen as well as the underlying genetic susceptibility of the child.

引用

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页码：49 / 55

页数：7

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