Body mass index (BMI) at an early age and the risk of dementia

被引：24

作者：

Chen, Yen-Ching ^{[2
,3
]}

Chen, Ta-Fu ^{[4
]}

Yip, Ping-Keung ^{[5
]}

Hu, Chi-Yin ^{[2
]}

Chu, Yi-Min ^{[6
,7
]}

Chen, Jen-Hau ^{[1
,2
,8
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Geriatr & Gerontol, Taipei 10002, Taiwan

[2] Natl Taiwan Univ, Coll Publ Hlth, Inst Prevent Med, Taipei 10055, Taiwan

[3] Natl Taiwan Univ, Coll Publ Hlth, Res Ctr Genes Environm & Human Hlth, Taipei 10055, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Neurol, Taipei 10002, Taiwan

[5] Cardinal Tien Hosp, Dept Neurol, Taipei 23148, Taiwan

[6] Cardinal Tien Hosp, Dept Lab Med, Taipei 23148, Taiwan

[7] Fu Jen Catholic Univ, Coll Med, Taipei 24205, Taiwan

[8] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10002, Taiwan

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 2010年 / 50卷

关键词：

Body mass index; Dementia; Alzheimer's disease; Vascular dementia; VASCULAR DEMENTIA; ALZHEIMERS-DISEASE; FOLLOW-UP; MIDLIFE; OVERWEIGHT; DIAGNOSIS; CRITERIA; SUBTYPES; OBESITY; FAT;

D O I：

10.1016/S0167-4943(10)70013-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

BMI change and BMI at an early age have not been investigated as risks for dementia. This case-control study included 286 dementia patients and 268 controls from two medical centers between 2007 and 2009. BMI information was collected from medical records and questionnaires. Men and women with low BMIs at the time of the study, in their 20s, and in their 40s had significantly increased risks of Alzheimer's disease (AD) (odds ratio = OR = 2.62-3.97) and increased vascular dementia (VaD) risk (20s and 40s: OR = 6.23-11.11) compared with those with normal BMIs. High BMI in the 20s and 40s was associated with increased VaD risk (OR = 15.29 and 10.32) among women. For BMI changes from the 20s or 40s, the second and third tertiles were significantly associated with decreased AD risk among women (OR = 0.15-0.35) compared to the first tertile. The third tertile of BMI change from the 20s or 40s was associated with decreased VaD risk among women (OR = 0.06 and 0.14). Low BMIs in the 20s and 40s were stronger predictors of AD and VaD. There was a U-shaped association between BMI at different ages and dementia among participants with VaD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：S48 / S52

页数：5

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