Synthesis of (Z) and (E) α-alkenyl phosphonic acid derivatives of purines and pyrimidines

被引：87

作者：

Lazrek, HB ^{[1
]}

Rochdi, A

Khaider, H

Barascut, JL

Imbach, JL

Balzarini, J

Witvrouw, M

Pannecouque, C

De Clercq, E

机构：

[1] Fac Sci Semlalia, Chim Bioorgan Lab, Marrakech, Morocco

[2] Univ Sci & Tech Montpellier 2, Chim Bioorgan Lab, Montpellier, France

[3] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

TETRAHEDRON | 1998年 / 54卷 / 15期

关键词：

D O I：

10.1016/S0040-4020(98)00107-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(Z) and (E)-2-(purin-9-yl/pyrimidin-1-yl)ethylen-1-ylphosphonic acid 10-18 were synthetized by Michael addition of heterocyclic base with the diethylethynylphosphonate and deprotection of the acyclic nucleoside phosphonate with bromotrimethylsilane. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3807 / 3816

页数：10

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