Decreased bone formation and osteopenia in mice lacking α-calcitonin gene-related peptide

被引：134

作者：

Schinke, T

Liese, S

Priemel, M

Haberland, M

Schilling, AF

Catala-Lehnen, P

Blicharski, D

Rueger, JM

Gagel, RF

Emeson, RB

Amling, M

机构：

[1] Univ Hamburg, Sch Med, Dept Trauma Hand & Reconstruct Surg, D-20246 Hamburg, Germany

[2] Univ Hamburg, Sch Med, Ctr Biomech, D-2000 Hamburg, Germany

[3] Univ Texas, MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

[4] Vanderbilt Univ, Sch Med, Dept Pharmacol Mol Physiol & Biophys, Nashville, TN 37212 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 12期

关键词：

calcitonin; calcitonin gene-related peptide; bone formation; osteoblast;

D O I：

10.1359/JBMR.040915

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We recently described an unexpected high bone mass phenotype in mice lacking the Calca gene that encodes CT and alphaCGRP. Here we show that mice specifically lacking alphaCGRP expression display an osteopenia caused by a decreased bone formation. These results show that alphaCGRP is a physiological activator of bone formation and that the high bone mass phenotype of the Calca-deficient mice is caused by the absence of CT.

引用

收藏

页码：2049 / 2056

页数：8

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