Emerging function and potential diagnostic value of circular RNAs in cancer

被引：174

作者：

Cui, Xianglun ^{[1
]}

Wang, Jianxun ^{[2
]}

Guo, Zongjun ^{[3
]}

Li, Mengyang ^{[2
]}

Li, Mingyu ^{[1
]}

Liu, Si ^{[1
]}

Liu, Haoran ^{[1
]}

Li, Wenjing ^{[1
]}

Yin, Xunhua ^{[1
]}

Tao, Jiaping ^{[1
]}

Xu, Wenhua ^{[1
]}

机构：

[1] Qingdao Univ, Dept Inspect, Fac Med, Qingdao 266003, Peoples R China

[2] Qingdao Univ, Inst Translat Med, Ctr Regenerat Med, Qingdao 266021, Peoples R China

[3] Qingdao Univ, Coll Med, Affiliated Hosp, Dept Geriatr Med, Qingdao 266003, Peoples R China

来源：

MOLECULAR CANCER | 2018年 / 17卷

基金：

中国国家自然科学基金;

关键词：

Circular RNA; Cancer; Biogenesis; Function; Biomarker; BLADDER-CANCER; LUNG-CANCER; OSTEOSARCOMA PROLIFERATION; HEPATOCELLULAR-CARCINOMA; TUMOR-GROWTH; BIOMARKER; EXPRESSION; PROGRESSION; BIOGENESIS; SPONGE;

D O I：

10.1186/s12943-018-0877-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

As a novel class of endogenous RNAs, circRNAs, have a covalently closed continuous loop, with neither a 5'to 3'polarity, nor a polyadenylated tail. Numerous circRNAs have been characterized by abundance, stabilization, conservation, and exhibit tissue/developmental stage-specific expression. Furthermore, circRNAs play vital roles in tumorigenesis and metastasis, such as functioning as a ceRNA or miRNA sponge, interacting with protein and encoding protein. Increasing evidence has revealed that it potentially serves as a required novel biomarker for cancer diagnosis. This review summarized the latest research on circRNAs, including its classification and biogenesis, mechanism and functions, as well as circRNAs in different cancers, as a potential biomarker.

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页数：14

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