NF-κB signaling:: Flipping the switch with polyubiquitin chains

被引：19

作者：

Ravid, T ^{[1
]}

Hochstrasser, M ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 20期

关键词：

D O I：

10.1016/j.cub.2004.09.074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein modification by ubiquitin has emerged as an important cellular regulatory mechanism. Recent studies illustrate the surprising ways in which polyubiquitin chains are manipulated in the regulation of NF-kappaB signaling.

引用

页码：R898 / R900

页数：3

共 12 条

[1] The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
Boone, DL
Turer, EE
Lee, EG
Ahmad, RC
Wheeler, MT
Tsui, C
Hurley, P
Chien, M
Chai, S
Hitotsumatsu, O
McNally, E
Pickart, C
Ma, A
[J]. NATURE IMMUNOLOGY, 2004, 5 (10) : 1052 - 1060
[2] PROTEIN-KINASES AND PHOSPHATASES - THE YIN AND YANG OF PROTEIN-PHOSPHORYLATION AND SIGNALING
HUNTER, T
[J]. CELL, 1995, 80 (02) : 225 - 236
[3] TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
Kanayama, A
Seth, RB
Sun, LJ
Ea, CK
Hong, M
Shaito, A
Chiu, YH
Deng, L
Chen, ZJ
[J]. MOLECULAR CELL, 2004, 15 (04) : 535 - 548
[4] Phosphorylation meets ubiquitination:: The control of NF-κB activity
Karin, M
Ben-Neriah, Y
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 : 621 - +
[5] Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice
Lee, EG
Boone, DL
Chai, S
Libby, SL
Chien, M
Lodolce, JP
Ma, A
[J]. SCIENCE, 2000, 289 (5488) : 2350 - 2354
[6] Multiple associated proteins regulate proteasome structure and function
Leggett, DS
Hanna, J
Borodovsky, A
Crosas, B
Schmidt, M
Baker, RT
Walz, T
Ploegh, H
Finley, D
[J]. MOLECULAR CELL, 2002, 10 (03) : 495 - 507
[7] OPIPARI AW, 1990, J BIOL CHEM, V265, P14705
[8] Ubiquitin in chains
Pickart, CM
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (11) : 544 - 548
[9] The novel functions of ubiquitination in signaling
Sun, LJ
Chen, ZJ
[J]. CURRENT OPINION IN CELL BIOLOGY, 2004, 16 (02) : 119 - 126
[10] Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk
Verma, R
McDonald, H
Yates, JR
Deshaies, RJ
[J]. MOLECULAR CELL, 2001, 8 (02) : 439 - 448

← 1 2 →