Synthesis and evaluation of novel chromogenic aminopeptidase substrates for microorganism detection and identification

被引：11

作者：

James, Arthur L.

Perry, John D.

Rigby, Annette

Stanforth, Stephen P. ^{[1
]}

机构：

[1] Northumbria Univ, Sch Appl Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

[2] Freeman Rd Hosp, Dept Microbiol, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

aminopeptidase; microorganism identification; microorganism detection; diagnostic reagents; chromogenic reagents; 9-(4'-aminophenyl)acridines;

D O I：

10.1016/j.bmcl.2006.11.088

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The amides 8a-e and 10a-c were prepared as chromogenic aminopeptidase substrates. A range of microorganisms were grown in the presence of these compounds and coloured colonies were produced in several cases after addition of acetic acid-thus giving potential methods for the detection of aminopeptidase activity and for microorganism identification. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1418 / 1421

页数：4

共 16 条

[1]

ACHESON RM, 1986, J CHEM RES, P3425

[2] METHODS FOR DISTINGUISHING GRAM-POSITIVE FROM GRAM-NEGATIVE BACTERIA [J].