Nuclear Receptor Regulation of the Adaptive Response of Bile Acid Transporters in Cholestasis

被引：88

作者：

Wagner, Martin ^{[1
]}

Zollner, Gernot ^{[1
]}

Trauner, Michael ^{[1
]}

机构：

[1] Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, Lab Expt & Mol Hepatol, A-8036 Graz, Austria

来源：

SEMINARS IN LIVER DISEASE | 2010年 / 30卷 / 02期

基金：

奥地利科学基金会;

关键词：

ABC transporters; bile acids; bilirubin; cholestasis; enterohepatic circulation; multidrug resistance (associated) proteins; nuclear receptors; adaptation; FARNESOID-X-RECEPTOR; VITAMIN-D-RECEPTOR; PRIMARY BILIARY-CIRRHOSIS; CONSTITUTIVE ANDROSTANE RECEPTOR; SMALL HETERODIMER PARTNER; SALT EXPORT PUMP; PRIMARY SCLEROSING CHOLANGITIS; ALPHA-OST-BETA; NF-KAPPA-B; CHOLESTEROL 7-ALPHA-HYDROXYLASE GENE;

D O I：

10.1055/s-0030-1253225

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although hereditary or acquired defects in hepatobiliary transporter systems cause or predispose to cholestasis, adaptive bile acid transporter changes can counteract cholestasis by reducing hepatocellular and systemic concentrations of retained cholephiles. An important level in the regulation of adaptive bile acid transporters and overflow pathways is mediated at the transcriptional level by nuclear hormone receptors. Moreover, therapeutic approaches targeting nuclear receptors in cholestasis may stimulate these adaptive changes and open a new perspective for the treatment of cholestatic liver diseases. This review gives a comprehensive overview on bile acid transporters in the enterohepatic circulation and their adaptive changes in response to cholestasis as well as the regulatory networks underlying these adaptive mechanisms.

引用

页码：160 / 177

页数：18

共 168 条

[1] Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes [J].