Tube or not tube: Remodeling epithelial tissues by branching morphogenesis

被引:222
作者
Affolter, M
Bellusci, S
Itoh, N
Shilo, B
Thiery, JP
Werb, Z
机构
[1] Univ Basel, Biozentrum, Abt Zellbiol, CH-4056 Basel, Switzerland
[2] Childrens Hosp Los Angeles, Dev Biol Program, Los Angeles, CA 90027 USA
[3] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan
[4] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
[5] Inst Curie, F-75248 Paris 05, France
[6] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
关键词
TRACHEAL CELL-MIGRATION; BHLH-PAS PROTEIN; MOLECULAR MECHANISMS; TRANSCRIPTION FACTOR; GENETIC-CONTROL; MAMMARY-GLAND; DROSOPHILA; FGF; ENCODES; MIDLINE;
D O I
10.1016/S1534-5807(02)00410-0
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Branching morphogenesis involves the restructuring of epithelial tissues into complex and organized ramified tubular networks. Early rounds of branching are controlled genetically in a hardwired fashion in many organs, whereas later, branching is stochastic, responding to environmental cues. We discuss this sequential process from formation of an organ anlage and invagination of the epithelium to branch initiation and outgrowth in several model systems including Drosophila trachea and mammalian lung, mammary gland, and kidney.
引用
收藏
页码:11 / 18
页数:8
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