Resolvins and protectins: Natural pharmacophores for resolution biology

被引：78

作者：

Levy, Bruce D. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2010年 / 82卷 / 4-6期

关键词：

LIPOXIN A(4) RECEPTOR; ANTIINFLAMMATORY ACTIONS; DOCOSAHEXAENOIC ACID; LIPID MEDIATORS; SEVERE ASTHMA; APOPTOTIC NEUTROPHILS; ACUTE-INFLAMMATION; NEUROPROTECTIN D1; ASPIRIN TREATMENT; CELL APOPTOSIS;

D O I：

10.1016/j.plefa.2010.02.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dietary ingestion of fish is associated with a reduced risk for many common human illnesses. Fish oils are enriched with n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. Resolvins and protectins are newly discovered mediators that are enzymatically generated from these n-3 fatty acid precursors to orchestrate inflammation resolution. These natural compounds and their mimetics are providing intriguing evidence in model systems and translational research for cellular and molecular mechanisms that are active during catabasis. This review provides information on the biosynthesis and actions of these recently identified chemical mediators with particular reference to resolution of mucosal inflammatory responses. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：327 / 332

页数：6

共 47 条

[1] The docosatriene Protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering [J].

Ariel, A ;

Li, PL ;

Wang, W ;

Tang, WX ;

Fredman, G ;

Hong, S ;

Gotlinger, KH ;

Serhan, CN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (52) :43079-43086

[2] Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression [J].

Ariel, Amiram ;

Fredman, Gabrielle ;

Sun, Yee-Ping ;

Kantarci, Alpdogan ;

Van Dyke, Thomas E. ;

D Luster, Andrew ;

Serhan, Charles N. .

NATURE IMMUNOLOGY, 2006, 7 (11) :1209-1216

[3] Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis [J].

Arita, M ;

Yoshida, M ;

Hong, S ;

Tjonahen, E ;

Glickman, JN ;

Petasis, NA ;

Blumberg, RS ;

Serhan, CN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (21) :7671-7676

[4] Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1 [J].

Arita, M ;

Bianchini, F ;

Aliberti, J ;

Sher, A ;

Chiang, N ;

Hong, S ;

Yang, R ;

Petasis, NA ;

Serhan, CN .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (05) :713-722

[5] Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation [J].

Arita, Makoto ;

Ohira, Taisuke ;

Sun, Yee-Ping ;

Elangovan, Siva ;

Chiang, Nan ;

Serhan, Charles N. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3912-3917

[6] Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions [J].

Arita, Makoto ;

Oh, Sungwhan F. ;

Chonan, Tomomichi ;

Hong, Song ;

Elangovan, Siva ;

Sun, Yee-Ping ;

Uddin, Jasim ;

Petasis, Nicos A. ;

Serhan, Charles N. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (32) :22847-22854

[7] Molecular circuits of resolution: Formation and actions of resolvins and protectins [J].

Bannenberg, GL ;

Chiang, N ;

Ariel, A ;

Arita, M ;

Tjonahen, E ;

Gotlinger, KH ;

Hong, S ;

Serhan, CN .

JOURNAL OF IMMUNOLOGY, 2005, 174 (07) :4345-4355

[8] Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution [J].

Campbell, Eric L. ;

Louis, Nancy A. ;

Tomassetti, Sarah E. ;

Canny, Geraldine O. ;

Arita, Makoto ;

Serhan, Charles N. ;

Colgan, Sean P. .

FASEB JOURNAL, 2007, 21 (12) :3162-3170

[9] Synthetic chemerin-derived peptides suppress inflammation through ChemR23 [J].

Cash, Jenna L. ;

Hart, Rosie ;

Russ, Andreas ;

Dixon, John P. C. ;

Colledge, William H. ;

Doran, Joanne ;

Hendrick, Alan G. ;

Carlton, Mark B. L. ;

Greaves, David R. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (04) :767-775

[10] Lipoxin A4 levels in asthma:: relation with disease severity and aspirin sensitivity [J].

Celik, G. E. ;

Erkekol, F. O. ;

Misirligil, Z. ;

Melli, M. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2007, 37 (10) :1494-1501

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