Spacing of cytochrome oxidase blobs in visual cortex of normal and strabismic monkeys

被引:28
作者
Murphy, KM
Jones, DG
Fenstemaker, SB
Pegado, VD
Kiorpes, L
Movshon, JA
机构
[1] McMaster Univ, Dept Psychol, Neural Org & Plast Lab, Hamilton, ON L8S 4K1, Canada
[2] McMaster Univ, Dept Biomed Sci, Neural Org & Plast Lab, Hamilton, ON L8S 4K1, Canada
[3] McMaster Univ, Dept Comp Sci, Hamilton, ON L8S 4K1, Canada
[4] NYU, Ctr Neural Sci, Howard Hughes Med Inst, New York, NY 10003 USA
关键词
D O I
10.1093/cercor/8.3.237
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Some models of visual cortical development are based on the assumption that the tangential organization of V1 is not determined prior to visual experience. In these models, correlated binocular activity is a key element in the formation of visual cortical columns, and when the degree of interocular correlation is reduced the models predict an increase in column spacing. To examine this prediction we measured the spacing of columns, as defined by cytochrome oxidase (CO) blobs, in the visual cortex of monkeys whose binocular vision was either normal or disrupted by a strabismus. The spatial distribution of blobs was examined in seven normal and five strabismic macaques. Tangential sections through the upper layers of the visual cortex were stained to reveal the two-dimensional (2D) pattern of CO blobs. Each blob was localized and their center-to-center spacing, packing arrangement and density were calculated using 2D nearest-neighbor spatial analyses. The mean center-to-center spacing of blobs (590 mu m for normally reared and 598 mu m for strabismic macaques) and the mean density of blobs (3.67 blobs/mm(2) for normally reared and 3.45 blobs/mm(2) for strabismic macaques) were not significantly different. In addition, the 2D packing arrangement of the blobs was not affected by strabismus. While it is clear that neural activity plays a key role in the elaboration and refinement of ocular dominance cortical modules, we conclude that it does not determine the spatial period of the pattern of CO blobs, This suggests that aspects of the neural circuitry underlying the columnar architecture of the visual cortex are established prenatally and its fundamental periodicity is not modifiable by experience.
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页码:237 / 244
页数:8
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