The cell biology of rabies virus: using stealth to reach the brain

被引：318

作者：

Schnell, Matthias J. ^{[1
,2
]}

McGettigan, James P. ^{[1
,2
]}

Wirblich, Christoph ^{[1
]}

Papaneri, Amy ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Jefferson Med Coll, Jefferson Vaccine Ctr, Philadelphia, PA 19107 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 01期

关键词：

VESICULAR STOMATITIS-VIRUS; CENTRAL-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE; MATRIX PROTEIN; P-PROTEIN; DNA VACCINATION; TRANSNEURONAL TRACER; LENTIVIRAL VECTORS; NONHUMAN-PRIMATES; PHOSPHOPROTEIN-P;

D O I：

10.1038/nrmicro2260

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Rabies virus, the prototypical neurotropic virus, causes one of the most lethal zoonotic diseases. According to official estimates, over 55,000 people die of the disease annually, but this is probably a severe underestimation. A combination of virulence factors enables the virus to enter neurons at peripheral sites and travel through the spinal cord to the brain of the infected host, where it often induces aggression that facilitates the transfer of the virus to a new host. This Review summarizes the current knowledge of the replication cycle of rabies virus and virus-host cell interactions, both of which are fundamental elements in our quest to understand the life cycle of rabies virus and the pathogenesis of rabies.

引用

页码：51 / 61

页数：11

共 143 条

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