Radical cyclization strategies for the formation of ring constrained tricyclic tropane analogues

被引：15

作者：

Hoepping, A

George, C

Flippen-Anderson, J

Kozikowski, AP

机构：

[1] Georgetown Univ, Med Ctr, Dept Neurol, Drug Discovery Program, Washington, DC 20007 USA

[2] USN, Struct Matter Lab, Res Lab, Washington, DC 20375 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)01288-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and efficient method for the construction of N,C3-constrained tropane derivatives has been developed. The key step of the reaction sequence involves either a 6- or a 7-trig radical cyclization. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：7427 / 7432

页数：6

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