Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice

被引:166
作者
Mizuno, M [1 ]
Morimoto, M [1 ]
Minato, K [1 ]
Tsuchida, H [1 ]
机构
[1] Kobe Univ, Grad Sch Sci & Technol, Div Sci Biol Resources, Kobe, Hyogo 6578501, Japan
关键词
Agaricus blazei; T-cell subsets; flow cytometry; immunomodulating activity; mushrooms;
D O I
10.1271/bbb.62.434
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Subset analysis of splenic lymphocytes using how cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and LSt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. C-13-NMR data indicates that the main component in the active polysaccharide is the complex of alpha-1,6- and alpha-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. He seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells.
引用
收藏
页码:434 / 437
页数:4
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