Recent advances in the genetics of severe childhood obesity

被引：81

作者：

Farooqi, IS

O'Rahilly, S

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

[2] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2000年 / 83卷 / 01期

关键词：

obesity; generic defect;

D O I：

10.1136/adc.83.1.31

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Childhood obesity is becoming a global epidemic. Twin studies suggest a heritability of fat mass, and disorders of energy balance that arise from genetic defects have been identified. In the past three years, five single gene disorders resulting in early onset obesity have been characterised. The discovery of these genetic defects has biological and clinical implications which are greater than the rarity of the individual diseases might suggest.

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页码：31 / 34

页数：4

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