On the role of prolyl oligopeptidase in health and disease

被引:205
作者
Garcia-Horsman, J. A.
Mannisto, P. T.
Venalainen, J. I.
机构
[1] Ctr Invest Principe Felipe, Valencia 46013, Spain
[2] Univ Kuopio, Dept Pharmacol & Toxicol, FIN-70211 Kuopio, Finland
[3] Univ Helsinki, Div Pharmacol & Toxicol, FIN-00014 Helsinki, Finland
基金
芬兰科学院;
关键词
prolyl oligopeptidase; neuropeptide metabolism; memory and learning; inositol cycle; substance P; arginine-vasopressin; thyroliberin; gonadoliberin;
D O I
10.1016/j.npep.2006.10.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Prolyl oligopeptidase (POP) is a serine peptidase which digests small peptide-like hormones, neuroactive peptides, and various cellular factors. Therefore, this peptidase has been implicated in many physiological processes as well as in some psychiatric disorders, most probably through interference in inositol cycle. Intense research has been performed to elucidate, on the one hand, the basic structure, ligand binding, and kinetic properties of POP, and on the other, the pharmacology of its inhibitors. There is fairly strong evidence of in vivo importance of POP on substance P, arginine vasopressin, thyroliberin and gonadoliberin metabolism. However, information about the biological relevance of POP is not yet conclusive. Evidence regarding the physiological role of POP is lacking, which is surprising considering that peptidase inhibitors have been exploited for drug development, some of which are currently in clinical trials as memory enhancers for the aged and in a variety of neurological disorders. Here we review the recent progress on POP research and evaluate the relevance of the peptidase in the metabolism of various neuropeptides. The recognition of novel forms and relatives of POP may improve our understanding of how this family of proteins functions in normal and in neuropathological conditions. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1 / 24
页数:24
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