Severe vincristine toxicity in combination with itraconazole

被引：36

作者：

Gillies, J

Hung, KA

Fitzsimons, E

Soutar, R ^{[1
]}

机构：

[1] Monklands Dist Gen Hosp, Dept Haematol, Airdrie, Scotland

[2] Univ Glasgow, Western Infirm, Dept Haematol, Glasgow G11 6NT, Lanark, Scotland

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 1998年 / 20卷 / 02期

关键词：

vincristine; itraconazole; neurotoxicity;

D O I：

10.1046/j.1365-2257.1998.00103.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report two patients with acute lymphoblastic leukaemia (ALL) who were entered into the current MRC adult ALL trial (UKALL XII) in whom unusually severe vincristine induced neurotoxicity developed. This appeared to be the result of an interaction with itraconazole suspension.

引用

页码：123 / 124

页数：2

共 5 条

[1]

Bohme A, 1995, ANN HEMATOL, V71, P311, DOI 10.1007/BF01697985

[2] INTENSIFICATION OF TREATMENT AND SURVIVAL IN ALL CHILDREN WITH LYMPHOBLASTIC-LEUKEMIA - RESULTS OF UK MEDICAL-RESEARCH-COUNCIL TRIAL UKALL-X [J].

CHESSELLS, JM ;

BAILEY, C ;

RICHARDS, SM ;

EDEN, OB ;

BARBOR, PRH ;

BARRETT, A ;

BARTON, C ;

BROADBENT, V ;

DEMPSEY, SI ;

DURRANT, J ;

EMERSON, P ;

EVANS, DIK ;

FENNELLY, JJ ;

GALTON, DAG ;

GIBSON, B ;

GRAY, R ;

HANN, IM ;

HARDISTY, RM ;

HILL, FGH ;

KERNAHAN, J ;

KING, DJ ;

LILLEYMAN, JS ;

MANN, J ;

MARTIN, J ;

MCELWAIN, TJ ;

MELLOR, ST ;

JONES, PHM ;

OAKHILL, A ;

PETO, J ;

RADFORD, M ;

REES, JKH ;

STEVENS, RF ;

SUMMERFIELD, GP ;

THOMPSON, EN .

LANCET, 1995, 345 (8943) :143-148

[3]

COMO JA, 1994, NEW ENGL J MED, V330, P263, DOI 10.1056/NEJM199401273300407

[4] VINCRISTINE TOXICITY IN 5 CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA [J].

MURPHY, JA ;

ROSS, LM ;

GIBSON, BES .

LANCET, 1995, 346 (8972) :443-443

[5]

ROWINSKY EK, 1996, CANC CHEMOTHERAPY BI, P263

← 1 →