Terminoside A, a new triterpene glycoside from the bark of Terminalia arjuna inhibits nitric oxide production in murine macrophages

被引：25

作者：

Ali, A

Kaur, G

Hamid, H

Abdullah, T

Ali, M ^{[1
]}

Niwa, M

Alam, MS

机构：

[1] Hamdard Univ, Fac Pharm, Dept Pharmacognosy & Phytochem, New Delhi, India

[2] Hamdard Univ, Fac Sci, Dept Chem, New Delhi 110062, India

[3] Hamdard Univ, Fac Sci, Dept Elementol & Toxicol, New Delhi, India

[4] Meijo Univ, Fac Pharm, Dept Chem, Nagoya, Aichi, Japan

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2003年 / 5卷 / 02期

关键词：

triterpene glycoside; terminoside A; nitric oxide;

D O I：

10.1080/1028602031000066834

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Terminoside A (1), a new oleanane-type triterpene was isolated from the acetone fraction of the ethanolic extract of stem bark of Terminalia arjuna . The structure was established as olean-1alpha,3beta,22beta-triol-12-en-28-oic acid-3beta- d -glucopyranoside. On the basis of spectral data and chemical reactions, terminoside A, potently inhibited nitric oxide (NO) production and decreased inducible nitric oxide synthase (iNOS) levels in lipopolysaccharide-stimulated macrophages.

引用

页码：137 / 142

页数：6

共 18 条

[1]

AGARWAL PK, 1992, PHYTOCHEMISTRY, V31, P3307

[2]

Ali M, 2001, TECHNIQUES TERPENOID, P384

[3]

BATHNER AA, 1984, J AM CHEM SOC, V106, P811

[4] SALUTARY EFFECT OF TERMINALIA-ARJUNA IN PATIENTS WITH SEVERE REFRACTORY HEART-FAILURE [J].