Induction of drug metabolism by nuclear receptor CAR: molecular mechanisms and implications for drug research

被引：42

作者：

Masahiko, N

Honkakoski, P

机构：

[1] Univ Kuopio, Dept Pharmaceut, FIN-70211 Kuopio, Finland

[2] NIEHS, Reprod & Dev Toxicol Lab, Pharmacogenet Sect, NIH, Res Triangle Pk, NC 27709 USA

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2000年 / 11卷 / 04期

基金：

芬兰科学院;

关键词：

drug metabolism; cytochrome P450; induction; gene expression; phenobarbital; nuclear receptor CAR;

D O I：

10.1016/S0928-0987(00)00112-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent findings indicate that induction of drug metabolism is regulated by activation of specific members of the nuclear receptor gene family. This minireview deals with the mechanisms by which phenobarbital and phenobarbital-type chemicals induce cytochrome P450 and other genes, and summarises the knowledge on the role of the constitutively active receptor CAR in the induction process. The potential implications of CAR-mediated induction for drug research and possible uses of CAR are also discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：259 / 264

页数：6

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