Plasmacytoid dendritic cells in immunity

被引：1299

作者：

Colonna, M ^{[1
]}

Trinchieri, G

Liu, YJ

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA

[2] Schering Plough Corp, Lab Immunol Res, F-69571 Dardilly, France

[3] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 12期

关键词：

D O I：

10.1038/ni1141

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Human and mouse plasmacytoid dendritic cells have been shown to correspond to a specialized cell population that produces large amounts of type I interferons in response to viruses, the so-called natural interferon-producing cells. As a result, intensive investigation is now focused on the potential functions of plasmacytoid dendritic cells in both innate and adaptive immunity. Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases.

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页码：1219 / 1226

页数：8

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